- First installment of a miniseries
- First instruction
- First instruction in many a homework assignment
- First instruction, often
- First instrument for many
- First instrument heard in the Beatles' "She's Leaving Home"
- First insurer to advertise on television
- First International Gymnastics Hall of Fame inductee
- First international rock band to play in Cuba (2016), with "the"
- First invitees
- First Irish Literature Nobelist
- First Irish Nobelist in Literature
- First Irishman to win a Nobel Prize
- First Ironman locale
- First island mentioned in "Kokomo"
- First Israeli ambassador to the UN
- First issue of business
- First Italian course?
- First item on a certain table
- First Japanese city to be hit by atomic bomb
- First Japanese luxury car
- First Japanese prime minister born after WWII
- First Japanese-Canadian MP
- First Jewish superstar in the major leagues
- first job title for many teenagers
- First Joe led
- First justice alphabetically in the history of the Supreme Court
- First K-pop group to have a #1 Billboard hit
- First K-Pop group to perform at the Grammys
- First Kentuckian?
- First killer
- First king buried in Westminster Abbey
- First king of England
- First king of Israel
- First king of Israel Abba of
- First king of Jordan
- First king of the Franks
- first king of the northern kingdom of Israel who led Israel into sin
- First Knight star
- First Knight star Richard
- First known asteroid
- First known Asteroid discovered in 1898
- First known name of Richard Starkey
- First Korean to win the Best Director Oscar
- first label Elvis
- First Labor P.M. to win consecutive terms
- First Lady
- First lady
- First lady ___ McKinley
- first lady 1940s agcy.
- First Lady after Bess
- First Lady after Eleanor
- First lady after Hillary
- First Lady after Lady Bird
- First lady after Laura
- First lady after Lou
- First lady and diplomat Roosevelt
- First lady before Abigail
- First lady before Bess
- First lady before Betty
- First Lady before Eleanor
- First lady before Hillary
- First lady before Mamie
- First lady before Michelle
- First lady between Bess and Jackie
- First lady between Eleanor and Mamie
- First lady between Lou and Bess
- First lady Bush
- first lady California A Santa
- First lady dubbed "Spiritual Leader of the Nation"
- First Lady Ford
- First lady from Texas
- First Lady Harrison
- First lady Hoover
- First Lady in 1900
- First Lady McKinley
- First lady Michelle
- First lady not married to a president?
- First Lady of ___ Lanka
- First Lady of 1900
- First lady of 2001 to '09
- First Lady of California
- First Lady of Civil Rights
- First Lady of Country Music
- First Lady of Jazz
- First Lady of Mount Olympus
- First lady of Olympus
- First lady of scat
- First lady of scat, familiarly
- First Lady of Song
- First Lady of Song Fitzgerald
- First lady of the 1910s
- First lady of the 1940s-'50s
- First lady of the 1950s
- First lady of the 1980s
- first lady of the 20s
- First lady on Mount Olympus
- First lady on Mt. Olympus
- First lady Peron
- First lady played by Madonna
- First lady prior to Michelle
- First Lady Roosevelt
- First Lady Soviet co-op
- First Lady title
- First lady who died in office
- First Lady whose maiden name was Duarte
- First lady with bangs
- First lady, often
- First lady, once
- First lady's first name
- First lady's garden
- First lady's garden site?
- First lady's home
- First lady's hype?
- First lady's man?
- First lady's mate?
- First lady's namesakes
- First lady's residence
- First Lady's title
- First laid 59-Across on
- First landfall north of Oman
- First Latin American Olympics host
- first Latin words
- First Latina Disney princess
- First launch in the space race
- First layer of furniture protection
- First leaders in bridge
- First leg of a triathlon
- First leg of an itinerary
- First leg of racing's Triple Crown
- First lessons
- First lessons in reading
- first letter
- First letter in "Thanatos"
- First letter in Bathsheba
- First letter in Israel
- First letter in the fourth quarter of the Greek alphabet
- first letter in the Greek alphabet
- First letter in the Greek spelling of "Psyche"
- first letter in the Hebrew alphabet
- First letter in the last third of the Greek alphabet
- First letter in the second quarter of the Greek alphabet
- First letter in the Torah
- First letter of "tsar" in Russian
- First letter of "zebra" when it rhymes with "Debra"
- First letter of 14-Across
- First letter of 30-Down
- First letter of a name
- first letter of Arabic alphabet
- first letter of Hebrew alphabet
- First letter of name
- First letter of the Arabic alphabet
- First letter of the Greek alphabet
- First letter of the Hebrew alphabet
- First letter of the NATO phonetic alphabet
- first letter of your first name
- First letter, in Hebrew
- First letter, to Aristotle
- First letters
- First letters learned
- FIRST Lieutenant (sl.)
- First Light
- FIRST light
- First light ... or a phenomenon suggested by this puzzle's seven sets of circled letters?
- First light of day
- first light of the day
- First lights
- First Lincoln
- first line
- First line in a newspaper story
- First line of "Misty"
- First line of "Moby-Dick"
- First line of a nursery rhyme
- First line of a Seuss classic
- First line of a three-line eatery sign
- First line of a three-line poem
- First line of many puns
- First line on an IRS form?
- First line on many a legal document
- First lines
- First Liston/Clay fight result, in brief
- First Literature Nobelist from Ireland
- First little bit of progress
- First little pig's building material
- First Little Pig's material
- First little piggy's destination
- First living designer exhibited at the Guggenheim
- First living magician with a star on the Hollywood Walk of Fame
- First look
- first love
- first love Hercules
- First love of Scarlett admirer
- First love, perhaps
- First loyalty, to Polonius
- First Lt.'s superior
- First ltr.
- first lunar phase
- First M.L.B. player to enter the Meikyukai (a Japanese baseball hall of fame)
- FIRST made
- FIRST magnitude star
- First major city north of Kuwait
- First major film to be shot on the ocean
- First major leaguer to hit 40 homers and steal 40 bases in a season
- First major leaguer with 4,000 hits
- First major publisher of board games in the U.S.
- First maker of a mass-produced, low-priced car
- First male hurricane (1979)
- First male on the cover of 'Vogue'
- First male to appear on the cover of Vogue
- First mammal to be cloned
- First Man
- FIRST man
- FIRST man (Pers. legend)
- FIRST man (pert. to)
- First man featured on the cover of the U.S. edition of Vogue
- First man in paradise
- First man in space
- First man in the Bible
- First man standing?
- First man to appear on the cover of Vogue
- First man to make the cover of the U.S. edition of Vogue
- First man-made Satellite
- First man-made space satellite
- First man, in Maori myth
- First man, in Maori mythology
- First manned mooncraft
- First manned ship on the moon
- First manned spacecraft on the moon
- First manuscript
- First martyr
- First martyr, according to Matthew
- First martyr, per Matthew
- First mass consumer product offering Wi-Fi
- First mass-marketed sneakers
- First mass-produced American car with pop-up headlights
- First mass-producer of cars
- First mass-production auto company outside the U.S.
- First massproduced auto
- First match
- First matchmaker?
- First Mate
- first mate
- First mate of Cap'n Crunch
- First mate of the Pequod
- First mate of TV
- first mate on boat
- First mate, say?
- First mate?
- First mate's agreement
- First mate's greeting?