- First field in an online form, often
- First Fiesta Bowl winner: Abbr.
- First FIFA World Cup winner
- First fifth of a Shakespeare play
- First fighter to KO Liston
- First fill-in on some IRS forms
- First film critic to win a Pulitzer
- First film directed by Streisand
- First film released on laserdisc
- First film Tarzan
- First film to gross $2 billion
- FIRST finger
- First fire sign
- First first lady
- First first lady in the White House
- First First Lady to announce the Best Picture winner at an Academy Awards ceremony
- First first name on the moon
- First first name?
- First five books of Old Testament
- FIRST five books of the Bible
- FIRST five books traditionally ascribed to Moses (O.T.)
- First flight
- First flight launch site
- First flight locale
- FIRST floor
- First Folio, e.g.
- First follower
- First food consumed for Iftar, often
- First Ford
- First Ford car
- FIRST form
- First form line, usually
- first form of a butterfly
- First four of a series
- First fratricide victim
- First free Internet service provider
- First French head of state?
- First French prime
- First fruit fancier
- First fruit locale
- FIRST fruit of benefice
- First fruit site
- First fruit-picker
- First fruit's locale?
- first fruits
- first fruits of the season
- First full mo. of autumn
- First full mo. of fall
- First full mo. of spring
- First full mo. with 15 Across
- First full month of D.S.T.
- First full month of Major League Baseball, often: Abbr.
- First full month of spring
- First full month of spring: Abbr.
- First full spring mo.
- First full spring month
- First full summer mo.
- First full-scale working model
- First G.O.P. presidential candidate
- First game
- First Game 32-card
- First game in a series
- FIRST game in series
- First game of a double-header
- First game of a doubleheader
- First game of a series
- First game of the season
- First game of the year
- First game of thseason
- First games of the season
- First garden
- First Garden area
- First garden site?
- First gardener
- First gear
- First gemstone mentioned in the Bible
- First Genesis victim
- FIRST gift
- First given name in the Bible
- FIRST glance
- First golfer to win all four majors
- First golfer to win the U.S., British and Canadian Opens in the same year
- First golfing U.S. president
- First Google search results, often
- First got acquainted
- First governor of Alaska
- First governor of Massachusetts
- First governor of the state of Alaska
- First grade
- First grade basics
- First grade lessons
- First grade romance
- First graders' work
- First Grammy Lifetime Achievement Award winner
- First Grammy Lifetime Achievement awardee
- First grandchild
- First grandfather
- First grandkid of Adam
- First grandmother
- First grandson in the Bible
- First granulated laundry soap
- First Great Lake, alphabetically
- First Greek consonant
- First Greek letter
- First Greek letter in "Psyche"
- First Greek letter, to El Greco
- First Greek letters
- First Greek vowel
- First Greek-American vice president
- First group of invitees
- First group seen in "Macbeth"
- First group to get invitations
- First group to get invites
- First group with a #1 Billboard hit, alphabetically
- First guy in Space
- First guy in the Bible
- First guy on the moon
- First habitat
- First hair remover to be marketed in cream form
- First half of a cassette
- First half of a doubleheader
- First half of a famous Park Avenue hotel name
- First half of a golf course
- First half of a hoo-ha
- First half of a Little Richard song title
- First half of a pronoun pair
- First half of a Senate vote
- First half of a swanky California neighborhood
- First half of an album
- First half of an attention-getter
- First half of an indirect course?
- First half of an inning
- First half of an Iowa city
- First half of an LP
- First half of C&W show
- First half of the alphabet?
- First half of the files?
- first hand reporter
- First hats-off words at a ball game?
- First head of Homeland Security
- First head of the NFL
- First Hebrew letter
- First Hebrew letter: Var.
- First Hebrew patriarch
- First Hebrew patriarch (Var.)
- First High Priest of the Bible
- First high priest of the Israelites
- first hindu god in a trinity
- first hindu got in a trinity
- First hit by the Moody Blues (whose title ends with an exclamation point)
- first hit by the police
- First hit for The 4 Seasons
- First hit for the Moody Blues
- first hit Gershwin biographer David
- First hit, perhaps
- First Hmong American to win an Olympic gold medal
- First hockey player to win Sports Illustrated's Sportsman of the Year
- First holder of the title Supreme Governor of the Church of England
- First hole of the back nine
- First Holy Roman emperor
- First Home
- First home of 15-Across
- First home of the Mets
- First home of the three rich little pigs?
- First home of the University of Nevada
- First home?
- First Homeland Security secretary
- First homicide victim
- First host of 'How to Boil Water'
- First host of "America's Funniest Home Videos"
- First host of "America's Got Talent"
- First host of "Jeopardy!"
- First host of "The Tonight Show"
- First host of 61-Down
- First House speaker from California
- First houseboat
- First human born
- First human born, according to the Bible
- First human character on "Sesame Street"
- First human in space
- First human to die
- First human virus to be isolated
- First husband
- First husband of Bathsheba
- First impeached U.S. president
- first importance
- first in
- First in "Who's Who in the Bible"
- First in a car, say
- First in a classical sequence
- First in a field
- First in a historical trio
- First in a horror film franchise
- First in a Latin 101 trio
- First in a Latin trio
- First in a line of 260+
- First in a line of cars
- First in a long line of sitcoms?
- First in a long line?
- First in a long series of movies
- First in a playoff series
- First in a race?
- First in a series
- First in a Series 1969 winners
- First in a series of 26
- First in a series of slasher flicks
- First in an infinite line
- First in an order
- First in business worldwide sloganeer
- First in command?
- First in courage
- First in degree
- First in double figures
- First in importance
- First in John Wayne's "Cavalry Trilogy"
- First in line
- First in line for the throne, perhaps
- First in line to the throne
- First in line, in a way
- First in line, perhaps
- First in line, say
- First in NYC, e.g.
- FIRST in order
- FIRST in order of appearance
- first in order of birth
- FIRST in preference
- First in quality
- First in rank
- first in series
- first in space American people
- first in the breach
- FIRST in the field
- First in the film credits
- First in the queue
- First in the race?
- First in the rankings
- First in the waiting line
- First in time
- first in time, place, or importance
- First in to bat
- First in, first out, e.g.
- First India 1998 headline event in
- First Indian P.M.
- First Indian P.M. 4
- First Indian prime minister
- First Indian Prime Minister 1950s British
- First Indian tribe met by Lewis and Clark
- First Indian tribe to sign a treaty with the U.S. government
- First Indochina War's Battle of Dien ___ Phu
- First inductee in the Modern Drummer Hall of Fame