- First appellation
- First apple user?
- First application blank
- First application line to fill in
- First Arab country to have sanctions imposed on it by the Arab League
- first Arabic letter
- First arboretum
- First Army first name
- First Army rank of 39-Across
- First arrival
- First arrival in 72 Across
- First Arthur C. Clarke Award winner
- First artificial earth satellite
- First artificial satellite
- First artist whose first six albums debuted at #1 on the Billboard 200
- First Asian city to host the Winter Olympics
- First Asian tennis player to be ranked #1 in singles
- First Asian-American Cabinet member
- First Asian-American NBA champion Jeremy
- First aspirin maker
- First assembly-line carmaker
- First assemblyman?
- First asteroid discovered
- First asteroid ever discovered
- First asteroid landed on by a NASA craft
- First asteroid landed on by a spacecraft
- First asteroid orbited by a NASA spacecraft
- First asteroid to be orbited
- First astrological sign
- first At a distance
- First athlete to appear on the cover of Time magazine
- First atomic bomb target
- First atomic Submarine
- First attempt
- First audience-participation TV talk show
- First auto to offer seat belts
- First auto with automatic transmission, for short
- First automaker to offer seatbelts as an option (1949)
- First available
- First baby picture, often
- First baby picture, perhaps
- First back ender
- First bad guy?
- First balconies
- First balcony
- First band, alphabetically, on many an iPod
- First bars of a musical composition/a piece of popular music
- First baseball Hall of Famer
- First Baseball Hall of Famer Ty
- First Baseball Hall-of-Famer, alphabetically
- First baseball player to make $1 million a year
- First baseball team to go undercover?
- FIRST BASEMAN
- First baseman Brogna
- First baseman in a classic comedy routine
- First baseman in a comedy routine
- First baseman in a famous comedy routine
- First baseman Martinez
- First baseman Mientkiewicz who caught the final out of the 2004 Boston World Series victory
- First baseman of comedy
- First baseman Palmeiro who was suspended for using steroids
- First baseman Prince of the Texas Rangers
- First baseman Wally most famous for being replaced by Lou Gehrig
- First baseman, to Abbott and Costello
- First baseman's glove
- First baseman's need
- First batsman
- FIRST batsman (crick.)
- First batter
- First batter to hit a home run against every Major League Baseball team
- First battery brand to feature an indefatigable pink bunny in its ads
- First bear to detect Goldilocks's intrusion
- First bearded prez
- First bed
- First Best Actor Oscar winner
- First Best Actor/Supporting Actor Oscar winner
- First Best Actress Oscar winner
- First Best Picture Oscar winner
- First bet in a summer World Series
- First beverage brand sold in six-packs
- First Bible bk.
- First Bible book
- First biblical birth
- First Biblical casualty
- First biblical victim
- first Bid
- First big song success for The Moody Blues
- First billed band
- First bird off the Ark, in Genesis
- First bird to attack in "The Birds"
- First bishop of Paris
- First bishop of Paris Info
- First bishop of Rome
- First bishop of Rome Ancient invader of
- First bk.
- First bk. of the bible
- First bk. of the Latter Prophets
- First black major-league baseball coach Buck ___
- First Black MLB team captain, 1964
- First Black NHL player Willie ___
- First black player on the US Davis Cup team
- First black woman in space, ___ Jemison
- First blank on many forms
- First blond Bond
- First Blood character
- First Blood director Kotcheff
- First Blood figure
- First Blood hero
- First Blood hero John
- First Blood protagonist
- FIRST blush
- First Bond actor born after the Bond films began
- First Bond flick
- First Bond movie
- First bone donor?
- First bone transplant donor?
- First book
- First book in a series about juniper berries?
- First book in the Book
- First book of Octavia Butler's "Lilith's Brood" series
- First book of Old Testament
- First book of the 12 Minor Prophets
- First book of the Bible
- First book of the Bible, alphabetically
- First book of the Great Plains trilogy
- First book of the New Testament
- first book of the torah
- first book of tohrah
- First book or coat
- First Born
- First born child
- first born child of odin
- First born, really
- first brewed in the Bohemian town of Pilsen
- First brewery to put beer in cans
- First British Best Musical Tony winner
- First British nuclear-powered submarine
- First British prime minister
- First broadcaster to sell streaming
- First Broadway play to star Mae West
- first bron
- First brother
- First Burmese P.M. 4
- First Burmese premier
- First Burmese prime minister
- First Burmese Prime Minister 1950s British
- First calendar pg.
- First call, perhaps
- First call?
- First called
- First Campbell's Soup flavor, introduced in 1895
- First Canadian born Prime Minister
- First Canadian Governor General of African descent
- First Canadian M.L.B. team
- First Canadian winner at Augusta
- First Canadian woman atop Everest
- First canonical hour
- First Capital
- First capital of Alaska
- first capital of australia
- First capital of California
- First capital of German Federal Republic
- First capital of Japan
- First capital of Nebraska city
- First capital of the kingdom of Italy
- First capital of unified Italy
- First captain?
- First car to offer seatbelts (1950)
- First car, for many?
- First car, often
- First card below the faces
- First cardinal in Mexico
- First carrier to offer regular in-flight movies, 1961
- First Cartesian
- First catch the fly, then eat the fly?
- First Catholic vice president of the U.S.
- First caucus state
- FIRST cause
- First celebrity on 'Sesame Street'
- FIRST cell of a new individual
- First cellular co. to offer service nationwide
- First century execution method
- First century Roman despot
- first cervical vertebra
- First chair in the air
- First chairman of the Joint Chiefs of Staff, 1949
- First chance, to a kid
- First chancr\tler of reunified germany
- First character in Genesis
- First character in this clue
- First character seen in "Zelig"
- First character to appear in "Carmen"
- First Chief Justice
- First Chief Justice 1836 64
- First Chief Justice afoot?
- First Chief Justice John
- First Chief Justice of the U.S.
- First Chief Justice of the United States
- First child
- First child of Henry VIII to survive to adulthood
- First child, 1977-81
- First chimp in orbit
- First chimp to orbit Earth
- First Chinese dynasty
- First Chinese-American cabinet member
- First chip
- First chip in
- First chip in a pot
- First chip in the poker pot
- First chip in the pot
- First chip thrown in
- First chip tossed in
- First chip, maybe
- First chip, often
- First chip, perhaps
- First chips
- First chips in the center
- First chips in the middle
- First chips in the pot
- First choice
- First choice of schemes
- First choice, slangily
- First Christian martyr
- First Christmas travelers?
- First Christmas visitors
- First CIA director under Reagan
- First CinemaScope movie
- First circle of hell in Dante's "Inferno"
- First circle on a Scantron sheet, often
- First city bombed in W.W. II's Baedeker Blitz
- First Claim
- First claim, in slang
- First claim, informally
- First claim, slangily
- First claim, so to speak
- First class alternative
- First class drinks partyWork out the answer
- First Class sailor
- First class, for short
- First class, slangily
- FIRST classman
- First cloned mammal
- First cloned primate
- First cloned sheep
- First clothing
- First club member
- First clue
- FIRST co-ordinate (geom.)
- First Coat
- First coat